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Weeds premiere: Mary-Louise Parker goes on the run!

Deanna Barnert covers entertainment from all the corners. Stay tuned to SheKnows for Deanna's in depth reports on everything you need to know about television, film and celeb gossip.

Mary-Louise Parker previews Weeds

Weeds went out with a bang, literally, last season. Tonight, Mary-Louise Parker's Nancy returns to Showtime and takes the Botwin clan on the run in the new season of Weeds. Big names like Richard Dreyfuss, Jennifer Jason-Leigh and Mark Paul Gosselaar are along for the ride in season six.

The youngest Botwin had been on the road to trouble for a while, but in the final moments of the Weeds season five finale, he arrived with fanfare!

Mary Louise Parker centers the cast of Weeds

Vicious Mexican cartel queen Pilar threatened Nancy's boys, so Shane came to the rescue and took out the vixen with a croquette mallet. The season closed with Pilar floating face-down in a pool, setting the ground for a Weeds reboot.

"Last season, to me, was kind of boring, but this season is much more interesting and funnier," Mary-Louise Parker promised at Comic-Con.

With a murder hanging over his head, young Shane remains disturbingly unruffled and Nancy has no time to get over the shock. She immediately rounds up the Botwins and takes the clan on the run.

Traveling under an assumed name, the "Newmans" head for Montana, Seattle and beyond, which means they'll be meeting a host of new folks this season.

Oscar-winner Richard Dreyfuss is set to appear in at least four episodes of Weeds, Alanis Morissette returns as Andy's girlfriend and Jennifer Jason-Leigh, Mark Paul Gosselaar, Peter Stormare and Linda Hamilton also join in on the action.

Unfortunately, Elizabeth Perkins won't return to go up against Parker as everyone's favorite villain, Celia Hodes.

"She was wonderful," Parker said of Perkins. "There's nothing bad I can say about her after six years. She's so smart, so kind, and hilarious. And I just loved her acting. I don't think anybody could have done what she did. I would watch her all the time and go: God, I would have never thought to do that."

Nancy also ditches her corrupt drug-dealing kingpin hubby Esteban Reyes, but she'll find a new hot and heavy but short term romance with Gosselaar's new character.

"I always wanted him for the part, and it wasn't going to work out, and then it did work out," Parker said at Comic-Con. "He showed up and knew all his lines and knew the script. He was more prepared than a lot of actors."

Nancy is set on going clean this season, but from the previews, it looks like she'll be tempted to get back into the drug trade. It's a whole strain of drama on Weeds this season, but some things never change.

Weeds returns at 10 pm on Showtime before the premiere of Laura Linney's The Big C.

Weeds new season preview

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