Inglourious Basterds finished first at the late-summer box office battle ahead of the sci-fi thriller District 9, Shorts and Time Traveler's Wife.
Pitt and his Basterds earned $37.6 million in its first week of release.
Tarantino has his first summer hit in years and Pitt continues his hot streak that most recently saw him earn an Oscar nomination for The Curious Case of Benjamin Button.
In second place was the Peter Jackson-produced District 9 that scared up another $18.9 to outpace GI Joe.
The second Hasbro toy-to-movie number one (the first was Transformers 2), added another $12.5 million to it's already impressive totals.
During its second week, most films take a nose dive in summer. It's great to see The Time Traveler's Wife building a head of steam heading into the fall film season.
Meryl Streep and Amy Adams continued to also equal box office gold. Their latest pairing, Julie and Julia earned another $9 million to take fifth place in the weekend box office. Streep and Adams last starred together in the Oscar-nominated Doubt.
In sixth place is Tarantino's BFF Rodriguez's latest family film, Shorts, that earned a strong G-rated $6.6 million. Watch for Shorts numbers to grow as younger kids cling to the final days of summer.
Inglourious Basterds gave Tarantino a career-best debut. Pitt and Tarantino can hope for second week totals to equal those of the Jackson-produced District 9. In two weeks of release, it has earned an astounding $73.5 million.
Diane Kruger dishes Inglourious Basterds
The Time Traveler's Wife page-to-screen journey
Rachel McAdams and Eric Bana share insight into The Time Traveler's Wife
Inside Julie and Julia with Meryl Streep and Amy Adams
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