The beauty and her husband, Peter Lanfer, are expecting their second child together, her rep confirmed to Us Weekly.
"Peter and I are delighted to announce our pregnancy," the actress told the magazine in a statement. "We can't wait to introduce Micah to his little brother or sister."
The lovebirds married in June 2002 but took their time before they started a family and only welcomed their first child, a son, in January 2012.
The Moms' Night Out actress is thrilled to be pregnant again, and her second bundle of joy will be due in December. Drew even shared her joy about her pregnancy with fans via Twitter on Tuesday.
"Nope. That's not a fake belly," the star tweeted.
The actress's character on the hit medical drama Grey's Anatomy is mimicking her own life, because on the season finale of the show her character April Kepner is expecting her first child with her on-screen husband Jackson Avery.
Luckily for the actress her costars are also super-helpful when it comes to babies and she previously revealed to Us Weekly that they rallied around her when she was pregnant with her son.
"I got great advice about nausea from Ellen Pompeo because I am still dealing with nausea, which is no fun," Drew previously told the magazine. "She's a wealth of information: She's done all the research and looked into every possible way of doing things.
"I've gotten some great advice from Jessica Capshaw, especially about the brand of Pampers I'm supposed to be using. But I'm like, 'Dude, I have some time,'" she added. "And I had great advice from Chyler Leigh about breastfeeding."
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