I'd never heard of "KLOTHO" until I read this article. It's a gene with a variant so strong that it may negate the notorious E4 variant of the APOE gene, which is a major factor in contributing to Alzheimer's.
The variant also seems to have major cognitive benefits for the young brain, improving learning and memory in those with higher levels of KLOTHO.
In a recent study, researchers looked at the results of 700 people who participated in aging studies. They found that those with variants of the KLOTHO gene scored better on cognitive tests.
They then genetically modified mice and found that those with elevated KLOTHO performed twice as well on cognitive tests, especially memory. When the scientists elevated the level of KLOTHO in mice they increased the flexibility of their brain connections and enhanced the formation of those neural connections.
I'm not sure what these means for the future. Will they start injecting stem cells with KLOTHO? (Does that even work?) But I do believe it creates hope - especially for those with the E4 variant of the APOE gene who feel they're destined to develop Alzheimer's.
Here's what I read:
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