Palm Springs, California
This desert oasis is the ultimate spot to unwind poolside. Book a room at a hip hotel like the Jonathan Adler–decorated Parker or the psychedelic Saguaro Palm Springs. If you're going with the family or your gal pals, consider one of the über-cool midcentury rental homes in the area.
If you fancy yourself a foodie, take a weekend jaunt to Portland. Check in at the LEED-certified The Nines and spend the weekend meandering through the many boutiques, eateries, cafés and brewpubs Portland has to offer. Get a window seat, settle in and soak up the hipster vibe of this quirky Northwestern city.
When it comes to spas, Tucson is a true desert oasis. The luxurious Miraval resort and spa spans 400 acres at the foot of the stunning Santa Catalina mountains. This award-winning destination offers yoga, meditation and fitness classes; nutrition and culinary classes; and desert-inspired spa treatments that will leave you in a state of bliss.
Santa Fe, New Mexico
The natural beauty, laid-back atmosphere and artisan community of Santa Fe have won the hearts of many a relaxation seeker. For the ultimate Santa Fe experience, treat yourself to a stay at The Inn and Spa at Loreto, a boutique luxury hotel located off the city's main plaza. Just minutes from downtown Santa Fe, you'll find Ten Thousand Waves, a Japanese-style hot-spring resort where you can soak your cares away in the clothing-optional hot tubs.
Glen Ellyn, Illinois
At the Inn at Water's Edge in Glen Ellyn, every room features floor-to-ceiling windows facing a serene lake. Enjoy the two on-site restaurants or venture out to the Honey Café for some "modern comfort food," followed by a little shopping on Main Street.
Wisconsin's capital city, Madison, is a diverse city offering good eats, all the charm you'd expect from a Midwestern university town and unparalleled leaf-peeping opportunities. Stay at the historic Mansion Hill Inn and take a leisurely drive down Route 7 to Shelbourne to see maple, ash and sumac trees showing off their fall colors.
The Berkshires of Massachusetts
If you're into art, music, antiques or stage shows, a weekend in the famed Berkshire Mountains of western Massachusetts is just what the doctor ordered. No trip to this cultural mecca is complete without a visit to Tanglewood. If you're there in summer, be sure to catch an alfresco concert.
Play the role of a New England prepster with a weekend visit to Kennebunkport. Rent a riverfront home or stay at the chic, coastal Tides Beach Club, where you can luxuriate in comfort and indulge in fresh Maine lobster and the Beach Club's signature cocktails.
Charleston, South Carolina
Head to Charleston for historic Southern charm and amazing culinary delights. Stay at the newly opened Zero George Street and sign up for an evening cooking class. Need some spa time? Check out Seeking Indigo, Charleston's top-rated holistic wellness center and day spa.
Sanibel Island, Florida
Give in to the urge to feel the sand between your toes and head south to Sanibel Island. This Florida beach is known for its abundance of shells, so be sure to bring a bucket. A mild climate and warm water temps make this an ideal beach destination all year long.
When planning your girl's getaway, check vrbo.com or HomeAway.com for a selection of luxury rentals. You may be surprised at the affordable selection — especially when you're sharing the cost with friends!
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